RESEARCH GRANT AWARDS

Cancer Research Summer Fellowship Program

Overcoming AML Resistance to VEN-AZA by inhibiting Complex I Activity with MCJ Mimetics

Targeting FAK and Ribosome Biogenesis in thyroid cancer

Overcoming Therapy Resistance via EHMT1/2 Targeting

PRPS1 is a new mediator of skeletal muscle atrophy in cancerinduced cachexia

Microbiota in the immunotherapy response of oral squamous cell carcinoma

CU-GENES (CU Genetic Engagement, Education, Screening

PAK2 inhibition of Myc oncogenes as a novel therapeutic option for pediatric cancer.

Mutation-driven Clonal expansions as both seed and soil in lung cancer initiation

Examining the metabolic fitness of the Adjunctive LATactivating CAR T cell against Acute Myeloid Leukemia

Fatigue Screening and Triage for the management of Pediatric cancer-related fatigue (FAST-PEDS)

Precision Surgery in Head and Neck Cancer with advanced Chemiluminescent Nanoprobes

Combination XPO1 Inhibition and Cellular Immunotherapy for the Treatment of Pediatric High-Grade Gliomas

Identification of kinase inhibitors that exhibit off-target activation of the Integrated Stress Response

AI-powered Drug Discovery focused on developing best-in Class KDM4 Inhibitors to advance Epigenetic therapy for Metastatic Colon Cancer

Determining, Identifying and Controlling Copy Number of Mesenchymal Genes During Epithelial to Mesenchymal Transition in Breast Cancer

Investigating the telomere-mitochondria connection in age-associated tumorigenesis

Targeting OCT1 mediated adaptive resistance in K-RAS mutant LUAD

Single cell functional genomics to track transcriptional fate of CAR-T cell responses to leukemia

Assessing the phenotypic effects of innervation in bladder cancer

Equine Model of Penile Carcinoma for Evaluation of Immune Responses to Novel Intratumoral Immunotherapy

Defining and targeting stress-induced translational control as a means to inhibit metastasis

Mechanisms and vulnerabilities of fatty acid metabolism in endocrine resistant breast cancer

Dissecting the functional consequences of aberrant mRNA splicing by U2AF1(S34F) in hematologic malignancy

Enhancing T-Cell Therapy through PLZF Modulation

Elucidating exceptional responders to cabozantinib using a novel functional assay

Practical translation of proteosome inhibition for posterior-fossa ependymoma

Pre-clinical investigation to support IIT of CDK7 Inhibition in Pediatric Embryonal CNS tumors

When CAR T Cells Fall Short: Leveraging CAR T Homing and Activation to Sensitize Tumors to Chemotherapy

Immune Targeting therapies to disrupt virus-associated lymphomas

Assessing the HDAC2/MTA3 Complex as an Epigenetic Driver in Gynecologic Carcinosarcomas

Enhancing Immune-Mediated Radiotherapy Efficacy in Murine models of Head and Neck Cancer through Peroxisome Proliferator-Activated Receptor Modulation

Evaluating IDH1 facilitation of radiation resistance in MYC-amplified MB

Leveraging Chemoimmunotherapy to improve treatments for newly diagnosed aggressive T-cell lymphomas

Preclinical testing of gated CAR-T cells in overcoming tumor antigen escape for effective immunotherapy against DIPG

Effect of p53 on CAR T cell efficacy against acute leukemia

To investigate the role of NLRP3 in Pancreatic Ductal Adenocarcinoma (PDAC)-associated chemotherapy tolerance

Investigation of cell-free DNA to define EWG-FLI1 activity in Ewing Sarcoma

The role of H3k4me3 remodeling in melanoma BRAF/MEK inhibitor resistance

Targeting the BMI1 oncogene mRNA using small molecules

Targeting CDK8 as a therapeutic approach for MYC driven medulloblastoma

Influenza virus infection in reawakening dormant metastatic breast tumor cells in the lung

Deconvoluting enhancer rewiring in giloma relapse following radiotherapy

Personalization of care for patients with advanced microsatellite stable colon cancer

Choosing the right target: comparing PIK3CA and AKT inhibition in HER2+PIK3CA-mutated breast cancer

Cancer Research Summer Fellowship Program

A feasibility study of family interviews after early death in childhood cancer

Understanding and inhibiting the EYA3 and PP2A-B55a interaction in triple-negative breast cancer

Development of Novel Dual CD99/B7-H3 immunotoxins against DIPG, a fatal brain tumor in children

The role of subcellular localization of FAK in thyroid cancer

Validation and Implementation of a pediatric Oncofertility Risk Calculator for Children Diagnosed with an Extracranial Solid Tumor

Cancer Research Summer Fellowship Program

Targeting Heme Metabolism to Enhance Sensitivity to Immunotherapy in Metastatic Triple-Negative Breast Cancer

Body heat activated storable, near-infrared, self-illuminating nanoprobes for in vivo optical imaging of cancer

Evaluating the Effects of Cannabis Use and Circulating Cannabinoids on Tumor Infiltrating Lymphocytes in Malignant Melanoma

Targeting RNA-binding protein, NUDT21, enhances CD19 abundance on human B-cell acute lymphoblastic leukemia cells

Assessing the Prevalence of DNA Rereplication During Epithelial to Mesenchymal Transition in Breast Cancer

Identifying clinical and genetic features associated with thyroid cancer risk of recurrence

Modulation of the immune suppressed tumor microenvironment in high grade serous ovarian cancer through interventions in the tryptophan catabolism pathway

Investigation of mechanisms and feasibility for chemo/radio-sensitization for cancer therapy by SQAP

Integration of single-nuclei RNA-sequencing and spatial transcriptomics to study the transformation of highly aggressive malignant peripheral nerve sheath tumors

Programmed death receptor (PD-L1) expression as a biomarker for tyrosine kinase inhibitor (TKI) efficacy among patients with ALK-rearranged NSCLC

Pre-clinical evaluation of "SMART CAR"-T cell therapy against primary and metastatic Ewing sarcoma

An ex-vivo organoid model to identify markers of lung adenocarcinoma premalignancy

Vitamin D synthetic lethal network across benign and metastatic cell lines

Understanding new mechanisms cooperating with the PAX3/FOX01 driver oncofusion in rhabdomyosarcoma

Antitumor and Antimetastatic Effects of MYC Depletion with Omacetaxine in Osteosarcoma

Pilot Development of an Enriched Cancer Database using Machine Learning Techniques

Role of Cancer-cell specific MHC II in regulating response to immune checkpoint inhibitors in lung cancer

Investigating the role of host Sash 1 expression in antitumor Immunity

CDK9 as a druggable mediator sustaining Myc-driven circuitry in medulloblastoma

Pre-clinical test of colorectal cancer therapy based on combinatorial activation of p53 and Integrated Stress Response

Anti-TIGIT antibody in combination with bevacizumab/DC101 and pembrolizumab in microsatellite stable colorectal cancer

Mechanisms of PBAF Remodeling Complex and Effect of Cancer Mutations

Establishing a novel orthotopic sinonasal carcinoma model in immunocompetent rats for translational radiation and immunotherapy research